Biotinoyl Tripeptide-1, also referred to as Biotinyl-GHK or Biotin-GHK, is a high-performance cosmeceutical peptide derived from the combination of biotin (Vitamin B7 or H) and the GHK tripeptide (glycine, histidine, lysine). It is a biomimetic peptide that stimulates hair follicle cells and promotes hair growth, making it an effective ingredient in hair care products. It is primarily used in hair loss treatment formulations, including hair growth serums, scalp treatments, and conditioning products. It is also gaining popularity in specialized applications such as Biotinoyl Tripeptide 1 eyelash formulations, where it is used to enhance the appearance of fuller and healthier lashes.
CAS No.: 299157-54-3
Synonyms: Biotinoyl GHK; Biotinoylglycylhistidyllysine
Biotinoyl Tripeptide-1 is sold under the commercial trade name Procapil (in combination formulations) and SpecPed BT1P.
| Properties | |
| Chemical formula | C24H38N8O6S |
| IUPAC name | (2S)-2-[[(2S)-2-[[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6, 6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]acetyl]amino] -3-(1H-imidazol-5-yl)propanoyl]amino]-6-aminohexanoic acid |
| Molecular weight | 566.7 g/mol |
| State | Powder |
| Color | White to off-white powder |
| Solubility | Soluble in water |
| Storage Conditions | 2–8°C |
| Parameter | Biotinoyl Tripeptide-1 | Minoxidil |
|---|---|---|
| Category | Cosmetic peptide ingredient | Pharmaceutical drug (OTC/Prescription) |
| Primary Use | Used in hair care and cosmetic formulations | Used for treatment of hair loss (androgenetic alopecia) |
| Mechanism | Supports scalp conditioning and hair structure via peptide signaling | Vasodilator that increases blood flow to hair follicles |
| Regulatory Status | Cosmetic ingredient | FDA-approved drug for hair loss treatment |
| Application Type | Shampoos, serums, conditioners, eyelash products | Topical solutions or foam |
| Side Effects | Minimal when used in cosmetic formulations | Possible irritation, dryness, shedding phase |
| Parameter | Biotinoyl Tripeptide-1 | Biotin (Vitamin B7) |
|---|---|---|
| Chemical Type | Biotin-conjugated peptide | Water-soluble vitamin (Vitamin B7) |
| Function in Formulations | Advanced peptide active with targeted cosmetic function | General conditioning and nutritional ingredients |
| Mechanism | Peptide signaling + biotin activity for improved hair appearance | Supports keratin infrastructure as a vitamin |
| Performance Level | High-performance cosmetic active | Basic functional ingredient |
| Application | Hair serums, scalp treatments, eyelash products | Shampoos, conditioners, supplements |
Biotinoyl Tripeptide-1 is generally considered safe for cosmetic use. It is well tolerated in topical applications and causes no irritation in properly formulated products. However, sensitivity may vary depending on formulation and individual skin type.
| Pictograms : |  |
| Hazard Statements : | H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation |
| Precautionary statements : | P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/protective clothing/eye protection/face protection. P302+P352 IF ON SKIN: Wash with plenty of soap and water. |
Biotinoyl Tripeptide-1, also referred to as Biotinyl-GHK or Biotin-GHK, is a high-performance cosmeceutical peptide derived from the combination of biotin (Vitamin B7 or H) and the GHK tripeptide (glycine, histidine, lysine). It is a biomimetic peptide that stimulates hair follicle cells and promotes hair growth, making it an effective ingredient in hair care products. It is primarily used in hair loss treatment formulations, including hair growth serums, scalp treatments, and conditioning products. It is also gaining popularity in specialized applications such as Biotinoyl Tripeptide 1 eyelash formulations, where it is used to enhance the appearance of fuller and healthier lashes.
CAS No.: 299157-54-3
Synonyms: Biotinoyl GHK; Biotinoylglycylhistidyllysine
Biotinoyl Tripeptide-1 is sold under the commercial trade name Procapil (in combination formulations) and SpecPed BT1P.
| Properties | |
| Chemical formula | C24H38N8O6S |
| IUPAC name | (2S)-2-[[(2S)-2-[[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6, 6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]acetyl]amino] -3-(1H-imidazol-5-yl)propanoyl]amino]-6-aminohexanoic acid |
| Molecular weight | 566.7 g/mol |
| State | Powder |
| Color | White to off-white powder |
| Solubility | Soluble in water |
| Storage Conditions | 2–8°C |
| Parameter | Biotinoyl Tripeptide-1 | Minoxidil |
|---|---|---|
| Category | Cosmetic peptide ingredient | Pharmaceutical drug (OTC/Prescription) |
| Primary Use | Used in hair care and cosmetic formulations | Used for treatment of hair loss (androgenetic alopecia) |
| Mechanism | Supports scalp conditioning and hair structure via peptide signaling | Vasodilator that increases blood flow to hair follicles |
| Regulatory Status | Cosmetic ingredient | FDA-approved drug for hair loss treatment |
| Application Type | Shampoos, serums, conditioners, eyelash products | Topical solutions or foam |
| Side Effects | Minimal when used in cosmetic formulations | Possible irritation, dryness, shedding phase |
| Parameter | Biotinoyl Tripeptide-1 | Biotin (Vitamin B7) |
|---|---|---|
| Chemical Type | Biotin-conjugated peptide | Water-soluble vitamin (Vitamin B7) |
| Function in Formulations | Advanced peptide active with targeted cosmetic function | General conditioning and nutritional ingredients |
| Mechanism | Peptide signaling + biotin activity for improved hair appearance | Supports keratin infrastructure as a vitamin |
| Performance Level | High-performance cosmetic active | Basic functional ingredient |
| Application | Hair serums, scalp treatments, eyelash products | Shampoos, conditioners, supplements |
Biotinoyl Tripeptide-1 is generally considered safe for cosmetic use. It is well tolerated in topical applications and causes no irritation in properly formulated products. However, sensitivity may vary depending on formulation and individual skin type.
| Pictograms : | |
| Hazard Statements : | H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation |
| Precautionary statements : | P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/protective clothing/eye protection/face protection. P302+P352 IF ON SKIN: Wash with plenty of soap and water. |
Biotinoyl tripeptide-1 is considered safe for cosmetic use when used in appropriate concentrations and properly formulated products.
Biotinoyl tripeptide-1 is compatible for use with shampoos, conditioners, and leave-in treatments.
It is commonly used in formulations designed to support the appearance of thicker, healthier hair and reduce hair breakage.
It is generally well-tolerated with no reported side effects when used in properly formulated cosmetic products.
