Hydroxyproline is a non-essential amino acid, a major constituent of collagen protein. It is obtained by the process of hydroxylation (addition of –OH group in the organic compounds) of proline with the help of prolyl-4-hydroxylase, followed by protein synthesis. It is a major constituent of protein collagen and plays a crucial role in collagen stability by forming a network of hydrogen bonds with the triple helix of collagen. Hydroxyproline prevents premature unfolding and increases the thermal stability of collagen.
CAS No.: 51-35-4
Synonyms: L-Hydroxyproline, trans-4-Hydroxy-L-proline, Hypro, hydroxy-L-proline, trans-L-Hydroxyproline, L-Proline, 4-hydroxy-, (4R)-, (4R)-4-hydroxy-L-proline
| Physical Properties | |
| Chemical formula | C5H9NO3 |
| IUPAC name | (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid |
| Molecular weight | 131.131 g·mol−1 |
| Solubility | Freely soluble in water; sparingly soluble in ethanol; insoluble in ether |
| Odor | Odorless |
| Taste | Slightly sweet |
| Color | White/Off-White |
| State | Crystal or powder |
| Boiling point | Decomposes |
| Melting point | 274 °C |
| Pictograms : | None |
| Hazard Statements : | H402: Harmful to aquatic life |
| Precautionary statements : | P273: Avoid release to the environment |
Hydroxyproline is a non-essential amino acid, a major constituent of collagen protein. It is obtained by the process of hydroxylation (addition of –OH group in the organic compounds) of proline with the help of prolyl-4-hydroxylase, followed by protein synthesis. It is a major constituent of protein collagen and plays a crucial role in collagen stability by forming a network of hydrogen bonds with the triple helix of collagen. Hydroxyproline prevents premature unfolding and increases the thermal stability of collagen.
CAS No.: 51-35-4
Synonyms: L-Hydroxyproline, trans-4-Hydroxy-L-proline, Hypro, hydroxy-L-proline, trans-L-Hydroxyproline, L-Proline, 4-hydroxy-, (4R)-, (4R)-4-hydroxy-L-proline
| Physical Properties | |
| Chemical formula | C5H9NO3 |
| IUPAC name | (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid |
| Molecular weight | 131.131 g·mol−1 |
| Solubility | Freely soluble in water; sparingly soluble in ethanol; insoluble in ether |
| Odor | Odorless |
| Taste | Slightly sweet |
| Color | White/Off-White |
| State | Crystal or powder |
| Boiling point | Decomposes |
| Melting point | 274 °C |
| Pictograms : | None |
| Hazard Statements : | H402: Harmful to aquatic life |
| Precautionary statements : | P273: Avoid release to the environment |
Hydroxyproline is present in the collagen protein as a major component. Hydroxyproline stabilises the helix structure of the collagen.
Hydroxyproline is a non-essential amino acid, meaning it is synthesised in the body from proline and does not need to be obtained through diet.
Hydroxyproline is not hydrophobic, it is hydrophilic as it gains hydroxyl group during the process of hydroxylation.
Hydroxyproline promotes skin hydration, collagen synthesis and helps in reducing wrinkles. It promotes wound healing and supports the structure of collagen.
