
2-Hydroxy-5-sulfobenzoic acid is an aromatic sulfonic acid that is a derivative of benzoic acid. It belongs to the benzoic acid, arenesulfonic acid and phenol families, and is known for its strong acidity and good hydrotropicity. The compound is available in several hydrated forms, such as dihydrate, trihydrate, and pentahydrate, and has been investigated as a benzoic acid derivative with acetylcholinesterase inhibitory activity.

CAS No.: 97-05-2
Synonyms: 5-sulfosalicylic acid, sulfosalicylic acid, salicylsulfonic acid, 2-hydroxy-5-sulfo, 2-hydroxysulfo, sulphosalicylic acid
| Physical Properties | |
| Chemical formula | C7H6O6S |
| IUPAC Name | 2-hydroxy-5-sulfobenzoic acid |
| Molecular weight | 218.19 g/mol |
| Solubility | Soluble in water |
| Appearance | Colorless to white crystals or a crystalline powder |
| Storage | Store at room temperature |
| Chemical Properties | |
| Color | Colorless |
| Physical State at 20 °C | Solid |
| Vapor Pressure | 0.005Pa at 20℃ |
| Odor | Odorless |
| Pictograms : | ![]() ![]() |
| Hazard Statements : | H314: Causes severe skin burns and eye damage |
| Precautionary statements : | P260: Do not breathe dust/fume/gas/mist/vapours/spray. P280: Wear protective gloves/protective clothing/eye protection/face protection/hearing protection. P301+P330+P331: IF SWALLOWED: rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310: Immediately call a POISON CENTER/doctor. P501: Dispose of contents/container to an industrial combustion plant.  |
2-Hydroxy-5-sulfobenzoic acid is an aromatic sulfonic acid that is a derivative of benzoic acid. It belongs to the benzoic acid, arenesulfonic acid and phenol families, and is known for its strong acidity and good hydrotropicity. The compound is available in several hydrated forms, such as dihydrate, trihydrate, and pentahydrate, and has been investigated as a benzoic acid derivative with acetylcholinesterase inhibitory activity.

CAS No.: 97-05-2
Synonyms: 5-sulfosalicylic acid, sulfosalicylic acid, salicylsulfonic acid, 2-hydroxy-5-sulfo, 2-hydroxysulfo, sulphosalicylic acid
| Physical Properties | |
| Chemical formula | C7H6O6S |
| IUPAC Name | 2-hydroxy-5-sulfobenzoic acid |
| Molecular weight | 218.19 g/mol |
| Solubility | Soluble in water |
| Appearance | Colorless to white crystals or a crystalline powder |
| Storage | Store at room temperature |
| Chemical Properties | |
| Color | Colorless |
| Physical State at 20 °C | Solid |
| Vapor Pressure | 0.005Pa at 20℃ |
| Odor | Odorless |
| Pictograms : | ![]() ![]() |
| Hazard Statements : | H314: Causes severe skin burns and eye damage |
| Precautionary statements : | P260: Do not breathe dust/fume/gas/mist/vapours/spray. P280: Wear protective gloves/protective clothing/eye protection/face protection/hearing protection. P301+P330+P331: IF SWALLOWED: rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310: Immediately call a POISON CENTER/doctor. P501: Dispose of contents/container to an industrial combustion plant.  |
2-Hydroxy-5-sulfobenzoic acid is mainly used for urine protein tests, protein precipitation, biochemical analysis, and laboratory research. It is also used as a hydrotropic agent in the pharmaceutical industry.
2-Hydroxy-5-sulfobenzoic acid is an organic aromatic sulfonic acid derived from benzoic acid and belongs to the classes of benzoic acids, phenols and arenesulfonic acids. Its structure carries both hydroxyl and sulfonic acid functional groups, which makes it a versatile reagent for analytical and laboratory applications.
2-Hydroxy-5-sulfobenzoic acid is used as an analytical reagent for determining urine proteins. It causes dissolved proteins to precipitate, producing turbidity that is measured to determine the presence and concentration of protein in urine samples in clinical laboratory testing.
The 2-Hydroxy-5-sulfobenzoic acid test can detect a wide range of urinary proteins, including albumin, globulins, and Bence Jones proteins and making it useful for screening abnormal protein levels.
2-Hydroxy-5-sulfobenzoic acid is also known as 5-sulfosalicylic acid or simply SSA. It is an aromatic sulfonic acid and a salicylic acid derivative commonly used as an analytical reagent in chemical, biochemical and clinical laboratories.