Cyanocobalamin

Properties of Cyanocobalamin

Uses of Cyanocobalamin

• Used as supplements for Vitamin B12 deficiency.
• Supports healthy Nervous system functioning, RBC production, and DNA synthesis.
• Injectable B12 (Cyanocobalamin) is used to treat methylmalonic aciduria.

Cyanocobalamin vs Methylcobalamin

• Cyanocobalamin is a synthetic form of vitamin B12 containing a cyanide group, while methylcobalamin is a natural, bioactive form with a methyl group.
• Cyanocobalamin is stable, cost-effective, and widely used in supplements and injections. However, it must be converted into active forms in the body, including methylcobalamin.
• Methylcobalamin does not require conversion and is directly involved in nerve function and methylation processes. It is especially beneficial in neurological disorders and Vitamin B12 deficiency with poor absorption.
• Cyanocobalamin has a better shelf life, while methylcobalamin offers higher bioavailability and is more efficient at supporting nerve health.
• Both share the same core B12 structure, but differ in their ligand attachments, affecting their biological roles and therapeutic uses.

Side effects of Cyanocobalamin

• Cyanocobalamin can cause shortness of breath, swelling, rapid weight gain, swollen tongue, and rash.
• Some individuals may experience leg cramps, hypokalemia, and sensations of tingling or numbness.
• In adverse conditions, pulmonary edema, congestive heart failure, and peripheral vascular thrombosis may occur.